Evaluating subjective domains of antipsychotic-induced adverse effects using heart rate variability.

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Evaluating subjective domains of antipsychotic-induced adverse effects using heart rate variability.

Psychiatry Clin Neurosci. 2014 Jul 28;

Authors: Chang JS, Hwang SS, Yi SH, Kim Y, Lee YS, Kim YS, Jung HY

Abstract
AIMS: Antipsychotic-induced autonomic dysregulation may lead to a wide range of subjective side effects in patients with schizophrenia. Using heart rate variability (HRV) measures, we prospectively examined the relationship between subjective side effects and cardiac autonomic regulation in unmedicated patients with schizophrenia.
METHODS: Forty-five unmedicated patients with schizophrenia were assessed for antipsychotic-associated side events and HRV parameters at the baseline and after 6-week treatment. Psychiatric symptoms and subjective side effects were assessed by the Positive and Negative Syndrome Scale (PANSS) and the Liverpool University Neuroleptic Side-effect Rating Scale (LUNSERS).
RESULTS: Correlations between subjective adverse effects and HRV measures at the baseline and at week 6 varied. Nonetheless, the changes in the psychic side effects domain were significantly correlated with the changes in time-domain HRV measures and sample entropy (SampEn). In addition, the change in the value of SampEn was significantly associated with those in the scores of extrapyramidal, anticholinergic, miscellaneous, and red herring domains as well as the mean total LUNSERS score.
CONCLUSION: Our results suggested that baseline HRV measures may predict clinical response and adverse events associated with treatment adherence. Also, subjective side effects may correspond well with the changes in neurocardiac dynamics and the changes in the values of SampEn may effectively reflect subjective discomfort in patients receiving antipsychotic treatment.

PMID: 25066617 [PubMed - as supplied by publisher]