Antidepressants and rapid-cycling bipolar II disorder: dogma, definitions and deconstructing discrepant data.

Related Articles

Antidepressants and rapid-cycling bipolar II disorder: dogma, definitions and deconstructing discrepant data.

Br J Psychiatry. 2013 Apr;202(4):251-2

Authors: Thase ME

Abstract
It is suggested that a finding that apparently challenges current practice guidelines, namely that patients with a rapid-cycling pattern of bipolar disorder can take antidepressant monotherapy for months without increasing risk of cycling, may be parsimoniously understood by the way that the investigators defined rapid cycling and by their use of acute-phase fluoxetine monotherapy prior to randomisation to continutaion-phase therapy with fluoxetine, lithium or placebo.

PMID: 23549940 [PubMed - indexed for MEDLINE]

Log In