[Long-acting injection – four-times-a-year. Review of the 3-monthly paliperidone-palmitate injection].

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[Long-acting injection – four-times-a-year. Review of the 3-monthly paliperidone-palmitate injection].
Psychiatr Hung. 2017;32(1):96-107
Authors: Herold R
Abstract
Continuous mainten…

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Why do psychiatric patients stop antipsychotic medication? A systematic review of reasons for nonadherence to medication in patients with serious mental illness.

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Why do psychiatric patients stop antipsychotic medication? A systematic review of reasons for nonadherence to medication in patients with serious mental illness.
Patient Prefer Adherence. 2017;11:449-468

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Suppression of Methamphetamine Self-Administration by Ketamine Pre-treatment Is Absent in the Methylazoxymethanol (MAM) Rat Model of Schizophrenia.

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Suppression of Methamphetamine Self-Administration by Ketamine Pre-treatment Is Absent in the Methylazoxymethanol (MAM) Rat Model of Schizophrenia.

Neurotox Res. 2017 Apr 18;:

Authors: Ruda-Kucerova J, Babinska Z, Stark T, Micale V

Abstract
Ketamine may prove to be a potential candidate in treating the widespread drug addiction/substance abuse epidemic among patients with schizophrenia. Clinical studies have shown ketamine to reduce cocaine and heroin cravings. However, the use of ketamine remains controversial as it may exacerbate the symptoms of schizophrenia. Therefore, the aim of this study is to characterize the effects of ketamine on drug addiction in schizophrenia using the methylazoxymethanol (MAM) acetate rat model on operant IV methamphetamine (METH) self-administration. MAM was administered intraperitoneally (22 mg/kg) on gestational day 17. Locomotor activity test and later IV self-administration (IVSA) were then performed in the male offspring followed by a period of forced abstinence and relapse of METH taking. After reaching stable intakes in the relapse phase, ketamine (5 mg/kg) was administered intraperitoneally 30 min prior to the self-administration session. As documented previously, the MAM rats showed a lack of habituation in the locomotor activity test but developed stable maintenance of METH self-administration with no difference in operant behaviour to control animals. Results show that ketamine treatment significantly reduced the METH intake in the control animals but not in MAM animals. Ketamine effect on METH self-administration may be explained by increased glutamatergic signalling in the prefrontal cortex caused by the N-methyl-D-aspartate antagonism and disinhibition of GABA interneurons which was shown to be impaired in the MAM rats. This mechanism may at least partly explain the clinically proven anti-craving potential of ketamine and allow development of more specific anti-craving medications with fewer risks.

PMID: 28421529 [PubMed – as supplied by publisher]

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Key updates in the clinical application of electroconvulsive therapy.

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Key updates in the clinical application of electroconvulsive therapy.
Int Rev Psychiatry. 2017 Apr 13;:1-9
Authors: Weiner RD, Reti IM
Abstract
ECT is the oldest and most effective …

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Comparison of Treatment Retention Between Risperidone Long-Acting Injection and First-Generation Long-Acting Injections in Patients With Schizophrenia for 5 Years.

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Comparison of Treatment Retention Between Risperidone Long-Acting Injection and First-Generation Long-Acting Injections in Patients With Schizophrenia for 5 Years.
J Clin Psychopharmacol. 2016 Aug;36(4):405…

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Deficits of perceived spatial separation induced prepulse inhibition in patients with schizophrenia: relationships to symptoms and neurocognition.

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Deficits of perceived spatial separation induced prepulse inhibition in patients with schizophrenia: relationships to symptoms and neurocognition.

BMC Psychiatry. 2017 Apr 11;17(1):135

Authors: Yang NB, Tian Q, Fan Y, Bo QJ, Zhang L, Li L, Wang CY

Abstract
BACKGROUND: Prepulse inhibition (PPI) and attention were impaired, which may cause psychotic symptoms and (or) hinder the cognitive functions in schizophrenia. However, due to the measurement methods of PPI, findings about the relationship between PPI and clinical symptoms, cognitive performances have been equivocal.
METHODS: Seventy-five schizophrenia patients (SZ) and 50 healthy controls (HC) were assessed in a modified acoustic PPI paradigm, named perceived spatial separation-induced PPI (PSS-PPI), compared to perceived spatial co-location PPI (PSC-PPI) with inter-stimulus interval (ISI) of 120 ms. Repeatable Battery for the Assessment of Neuropsychological Status and the Stroop Color-Word Test were administered to all subjects.
RESULTS: Significant decrease in the modified PPI was found in the patients as compared to the controls, and effect sizes (Cohen’d) for patients vs. HCs % PPI levels achieved a significant level (PSC-PPI d = 0.84, PSS-PPI d = 1.27). A logistic regression model based on PSS-PPI significantly represented the diagnostic grouping (χ(2)= 29.3; p < 0 .001), with 85.2% area under ROC curve in predicting group membership. In addition, patients exhibited deficits in neurocognition. Among patients of “non-remission”, after controlling for gender, age, education, duration, recurrence times, onset age, cigarettes per day and chlorpromazine equivalent dosage, PSS-PPI levels were associated with positive and negative symptoms, PANSS total and thought disorder (P1, P6, P7, N5, N7, G9). In multiple linear regression analyses, male and higher attention scores contributed to better PSC-PPI and PSS-PPI in controls group, while larger amount of smoke and longer word-color interfere time contributed to poor PSS-PPI. In patients’ group, higher education and attention scores contributed to better PSS-PPI, while repeated relapse contributed to poor PSS-PPI.
CONCLUSIONS: The acoustic perceived spatial separation-induced PPIs may bring to light the psychopathological symptoms, especially for thought disorder, and the mechanism(s) of the novel PPI paradigm was associated with attention function.

PMID: 28399842 [PubMed – in process]

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Do Family Interventions Improve Outcomes in Early Psychosis? A Systematic Review and Meta-Analysis.

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Do Family Interventions Improve Outcomes in Early Psychosis? A Systematic Review and Meta-Analysis.
Front Psychol. 2017;8:371
Authors: Claxton M, Onwumere J, Fornells-Ambrojo M
Abstract

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Alcohol Use and Service Utilization Among Veterans in Treatment for Schizophrenia.

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Alcohol Use and Service Utilization Among Veterans in Treatment for Schizophrenia.
Psychol Serv. 2017 Mar 13;:
Authors: Pedersen ER, Huang W, Cohen AN, Young AS
Abstract
Comorbid alc…

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Mixed features: evolution of the concept, past and current definitions, and future prospects.

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Mixed features: evolution of the concept, past and current definitions, and future prospects.
CNS Spectr. 2017 Mar 07;:1-9
Authors: Swann AC
Abstract
Mixed states address the relatio…

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Occlusal Dysesthesia: A Clinical Report on the Psychosomatic Management of a Japanese Patient Cohort.

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Occlusal Dysesthesia: A Clinical Report on the Psychosomatic Management of a Japanese Patient Cohort.
Int J Prosthodont. 2017 Mar/Apr;30(2):142-146
Authors: Oguchi H, Yamauchi Y, Karube Y, Suzuki N,…

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