Management of complications of ketamine abuse: 10 years’ experience in Hong Kong.

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Management of complications of ketamine abuse: 10 years’ experience in Hong Kong.
Hong Kong Med J. 2018 Apr 06;:
Authors: Hong YL, Yee CH, Tam YH, Wong JH, Lai PT, Ng CF
Abstract
Ket…

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Maintenance ECT in schizophrenia: A systematic review.

Maintenance ECT in schizophrenia: A systematic review.
Psychiatry Res. 2018 Mar 20;264:131-142
Authors: Ward HB, Szabo ST, Rakesh G
Abstract
Relapse after discontinuation of ECT is significant in pa…

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The utility of novel outcome measures in a naturalistic evaluation of schizophrenia treatment.

The utility of novel outcome measures in a naturalistic evaluation of schizophrenia treatment.
Neuropsychiatr Dis Treat. 2018;14:681-691
Authors: Tompsett T, Masters K, Donyai P
Abstract
Background:…

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Patterns of Prescription of Psychotropic Medications and Their Adherence among Patients with Schizophrenia in Two Psychiatric Hospitals in Accra, Ghana: A Cross-Sectional Survey.

Patterns of Prescription of Psychotropic Medications and Their Adherence among Patients with Schizophrenia in Two Psychiatric Hospitals in Accra, Ghana: A Cross-Sectional Survey.
Psychiatry J. 2018;2018:9850594
Auth…

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Coping strategies and self-esteem in the high-risk offspring of bipolar parents.

Coping strategies and self-esteem in the high-risk offspring of bipolar parents.

Aust N Z J Psychiatry. 2018 Mar 01;:4867418761577

Authors: Goodday SM, Bentall R, Jones S, Weir A, Duffy A

Abstract
OBJECTIVES: This study investigated whether there were differences in coping strategies and self-esteem between offspring of parents with bipolar disorder (high-risk) and offspring of unaffected parents (control), and whether these psychological factors predicted the onset and recurrence of mood episodes.
METHODS: High-risk and control offspring were followed longitudinally as part of the Flourish Canadian high-risk bipolar offspring cohort study. Offspring were clinically assessed annually by a psychiatrist using semi-structured interviews and completed a measure of coping strategies and self-esteem.
RESULTS: In high-risk offspring, avoidant coping strategies significantly increased the hazard of a new onset Diagnostic and Statistical Manual of Mental Disorders, 4th Edition twice revised mood episode or recurrence (hazard ratio: 1.89, p = 0.04), while higher self-esteem significantly decreased this hazard (hazard ratio: 2.50, p < 0.01). Self-esteem and avoidant coping significantly interacted with one another ( p < 0.05), where the risk of a Diagnostic and Statistical Manual of Mental Disorders, 4th Edition twice revised new onset mood episode or recurrence was only significantly increased among high-risk offspring with both high avoidant coping and low self-esteem.
CONCLUSION: A reduction of avoidant coping strategies in response to stress and improvement of self-esteem may be useful intervention targets for preventing the new onset or recurrence of a clinically significant mood disorder among individuals at high familial risk.

PMID: 29536749 [PubMed – as supplied by publisher]

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Can a digital medicine system improve adherence to antipsychotic treatment?

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Can a digital medicine system improve adherence to antipsychotic treatment?
Epidemiol Psychiatr Sci. 2018 Mar 12;:1-3
Authors: Papola D, Gastaldon C, Ostuzzi G
Abstract
A substantial…

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Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders.

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Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders.

J Inherit Metab Dis. 2018 Mar 09;:

Authors: Mocking RJT, Assies J, Ruhé HG, Schene AH

Abstract
Continuous research into the pathophysiology of psychiatric disorders, such as major depressive disorder (MDD), posttraumatic stress disorder (PTSD), and schizophrenia, suggests an important role for metabolism. This narrative review will provide an up-to-date summary of how metabolism is thought to be involved in the pathophysiology of these psychiatric disorders. We will focus on (I) the important role of fatty acids in these metabolic alterations, (II) whether fatty acid alterations represent epiphenomena or risk factors, and (III) similarities and dissociations in fatty acid alterations between different psychiatric disorders. (Historical) epidemiological evidence links fatty acid intake to psychiatric disorder prevalence, corroborated by altered fatty acid concentrations measured in psychiatric patients. These fatty acid alterations are connected with other concomitant pathophysiological mechanisms, including biological stress (hypothalamic-pituitary-adrenal (HPA)-axis and oxidative stress), inflammation, and brain network structure and function. Metabolomics and lipidomics studies are underway to more deeply investigate this complex network of associated neurometabolic alterations. Supplementation of fatty acids as disease-modifying nutraceuticals has clinical potential, particularly add-on eicosapentaenoic acid (EPA) in depressed patients with markers of increased inflammation. However, by interpreting the observed fatty acid alterations as partly (mal)adaptive phenomena, we attempt to nuance translational expectations and provide new clinical applications for these novel neurometabolic insights, e.g., to predict treatment response or depression recurrence. In conclusion, placing fatty acids in context can contribute to further understanding and optimized treatment of psychiatric disorders, in order to diminish their overwhelming burden of disease.

PMID: 29524021 [PubMed – as supplied by publisher]

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Medication adherence in first-episode psychosis patients in Singapore.

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Medication adherence in first-episode psychosis patients in Singapore.
Early Interv Psychiatry. 2018 Mar 09;:
Authors: Tan C, Abdin E, Liang W, Poon LY, Poon NY, Verma S
Abstract
AIM…

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Electronic monitoring in bipolar disorder.

Electronic monitoring in bipolar disorder.

Dan Med J. 2018 Mar;65(3):

Authors: Faurholt-Jepsen M

Abstract
Major reasons for the insufficient effects of current treatment options in bipolar disorder include delayed intervention for prodromal depressive and manic symptoms and decreased adherence to psychopharmacological treatment. The reliance on subjective information and clinical evaluations when diagnosing and assessing the severity of depressive and manic symptoms calls for less biased and more objective markers. By using electronic devices, fine-grained data on complex psychopathological aspects of bipolar disorder can be evaluated unobtrusively over the long term. Moreover, electronic data could possibly represent candidate markers of diagnosis and illness activity in bipolar disorder and allow for early and individualized intervention for prodromal symptoms outside clinical settings. 
The present dissertation concerns the use of electronic monitoring as a marker and treatment intervention in bipolar disorder and investigated the scientific literature and body of evidence within the area, which includes ten original study reports and two systematic reviews, one of which included a meta-analysis, conducted by the author of the dissertation. 
Taken together, the literature presented in this dissertation illustrates that 1) smartphone-based electronic self-monitoring of mood seems to reflect clinically assessed depressive and manic symptoms and enables the long-term characterization of mood

instability in bipolar disorder; 2) preliminary results suggest that smartphone-based automatically generated data (e.g. the number of text messages sent/day; the number of incoming and outgoing calls/day; the number of changes in cell tower IDs/day; and voice features) seem to reflect clinically assessed depressive and manic symptoms in bipolar disorder; 3) smartphone-based electronic self-monitoring had no effects on the severity of depressive and manic symptoms in bipolar disorder, according to a randomized controlled trial; and 4) electronic monitoring of psychomotor activity and heart rate variability seems to reflect illness activity in bipolar disorder and differentiate between patients with bipolar disorder and healthy control individuals. 
These findings point toward the usefulness of electronic monitoring as a marker of illness in bipolar disorder. Using electronic monitoring as a treatment intervention could provide innovative and novel interventions on-demand with a potential global reach, filling the gap between availability and the need for treatment. However, future studies using rigorous methodology and more randomized controlled trials that carefully investigate the positive effects and possible harmful effects of electronic monitoring in bipolar disorder are needed. In addition, patient safety, privacy issues, data security and legal aspects are major concerns that must be considered and addressed when using electronic monitoring.

PMID: 29510813 [PubMed – in process]

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Relapse prediction in schizophrenia through digital phenotyping: a pilot study.

Relapse prediction in schizophrenia through digital phenotyping: a pilot study.
Neuropsychopharmacology. 2018 Feb 22;:
Authors: Barnett I, Torous J, Staples P, Sandoval L, Keshavan M, Onnela JP
Abstract

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