Illness insight and neurophysiological error-processing deficits in schizophrenia.

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Illness insight and neurophysiological error-processing deficits in schizophrenia.

Schizophr Res. 2014 Jun;156(1):122-7

Authors: Kansal V, Patriciu I, Kiang M

Abstract
Impaired illness insight in schizophrenia is associated with non-adherence and worse outcomes. Schizophrenia patients also exhibit error-monitoring deficits, which have been proposed to cause poor insight. To test this hypothesis, we examined whether schizophrenia patients' deficits in neurophysiological error-monitoring indices, the error-related negativity (ERN) and error positivity (Pe) event-related potential (ERP) amplitudes, are associated with impaired insight. ERPs were recorded in 18 schizophrenia patients and 18 normal comparison participants during a Stroop task. Patients' subnormal ERN and Pe amplitudes did not correlate with insight, suggesting that impaired insight in schizophrenia stems from neurocognitive mechanisms other than deficient error monitoring.

PMID: 24739490 [PubMed - in process]