A Subgroup Analysis of Chinese Patients Switched to Paliperidone Palmitate One-Month Injectable by Prior Oral Antipsychotic Treatment.

A Subgroup Analysis of Chinese Patients Switched to Paliperidone Palmitate One-Month Injectable by Prior Oral Antipsychotic Treatment.

Pharmacopsychiatry. 2015 Dec 17;

Authors: Si T, Fan J, Wang X, Wang C, Xu C, Zhuo J, Feng Y

Abstract
Introduction: Safely tapering current antipsychotic medication, while balancing efficacy and tolerability, is an important consideration when switching patients from their antipsychotic therapy to a new treatment. The efficacy and tolerability of paliperidone palmitate one-month (PP1M) in Chinese patients switched from previous antipsychotic treatments were examined in order to develop effective switching and dosing strategies. Methods: A 13-week open-label, single arm, prospective, interventional study was conducted in Chinese patients (n=610) with acute schizophrenia to examine their response, by previous treatment group, when switched to PP1M (75-150 mg eq). Results: Among 610 patients with ≥30% reduction in PANSS total score were 191/263 (72.6%) risperidone/paliperidone extended-release patients, 36/52 (69.2%) olanzapine patients, and 214/293 (73.0%) other antipsychotic patients. Patient functioning and adherence were significantly (p≤0.05) improved for all subgroups. Discussion: Patients on higher doses of prior antipsychotics generally took longer to withdraw from their current medication. Most patients were administered the 100 mg eq dose, and all subgroups received a similar mean dose (114-119 mg eq) of PP1M. Recommendations for transitioning patients to PP1M from each subgroup are discussed.

PMID: 26679089 [PubMed - as supplied by publisher]

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