Factors associated with subjective side-effects during clozapine treatment.

Factors associated with subjective side-effects during clozapine treatment.

Nord J Psychiatry. 2014 Sep 16;:1-6

Authors: Seppälä N, Leinonen E, Viikki M, Solismaa A, Nuolivirta T, Kampman O

Abstract
Objective: Clozapine is associated with subjectively unpleasant or clinically serious side-effects, which may affect treatment adherence. The aims of the study were to explore the association of clozapine+ norclozapine serum concentration and other factors with subjective side-effects in schizophrenia patients. Methods: In this cross-sectional study, 237 patients with a diagnosis of schizophrenia, schizo-affective or other non-organic psychoses completed the Liverpool University Neuroleptic Side Effect Rating Scale (LUNSERS), a self-report scale measuring side-effects of antipsychotics and a clinical questionnaire. Clozapine+ norclozapine serum concentration of 190 patients was measured. Of the patients 80 (33.7%) were on antipsychotic combination therapy. Results: Higher clozapine+ norclozapine concentrations were associated with the depression-anxiety factor of LUNSERS and antipsychotic combination treatments were associated with sympatichotonia-tension factor. Younger patients reported sedation more often than older patients. Conclusion: According to the present results, high clozapine concentrations were associated with depression-anxiety symptoms, but the causality remains unknown.

PMID: 25225739 [PubMed - as supplied by publisher]