Outcome of Mood Stabilizer Discontinuation in Bipolar Disorder After 5 Years of Euthymia.

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Outcome of Mood Stabilizer Discontinuation in Bipolar Disorder After 5 Years of Euthymia.

J Clin Psychopharmacol. 2014 Jun 17;

Authors: Sharma PS, Kongasseri S, Praharaj SK

Abstract
OBJECTIVE: The objective was to study the outcome of mood stabilizer discontinuation on recurrence in patients with bipolar disorder after at least 5 years of euthymia.
METHODS: Twenty-three patients diagnosed with bipolar affective disorder according to the International Classification of Diseases, 10th Revision Diagnostic Criteria for Research, receiving mood stabilizer prophylaxis for at least 5 years, had undergone planned discontinuation, and the rates and time to recurrence were studied.
RESULTS: Twenty (87%) of 23 patients had recurrence, and all of the episodes were manic. Kaplan-Meier survival analysis showed median time to recurrence following discontinuation of mood stabilizer prophylaxis was 10 months (SE, 6.06 months; 95% confidence interval, 0 to 21.89 months).
CONCLUSION: Four fifths of our patients had recurrence following discontinuation of mood stabilizer prophylaxis within 10 months.

PMID: 24943387 [PubMed - as supplied by publisher]