Making the link between science and symptoms in schizophrenia.

Making the link between science and symptoms in schizophrenia.

J Clin Psychiatry. 2015 Jun;76(6):e15

Authors: Kane JM, Correll CU

Abstract
The majority of first-episode schizophrenia patients respond well to initial antipsychotic treatment, yet less than 1 in 5 will maintain recovery over 2 to 5 years, and most will experience at least one relapse. This response and lack of recovery may be due to antipsychotic efficacy for positive symptoms but not negative and cognitive symptoms. Recent research into the pathophysiology and treatment of schizophrenia has led to moving beyond the dopamine dysfunction to targeting other neurotransmitter systems to enhance the therapeutic response. This CME video covers the neuroscience behind schizophrenia, why certain medications are effective for some types of symptoms but not others, and what future types of medications may help to manage patients with difficult-to-treat symptoms.

PMID: 26132677 [PubMed - as supplied by publisher]

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