The effects of switching from oral to LAI antipsychotic treatment on subjective experience of schizophrenic and schizoaffective patients: preliminary results.

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The effects of switching from oral to LAI antipsychotic treatment on subjective experience of schizophrenic and schizoaffective patients: preliminary results.

Int J Psychiatry Clin Pract. 2014 Nov 20;:1-24

Authors: Pietrinia F, Spadaforaa M, Talambaa GA, Godinia L, Lellia L, Arcabassoa S, Manettib M, Ballerinia A

Abstract
ABSTRACT Objective: To present real-world preliminary evidence on the specific effects of switching from oral to long-acting injectable (LAI) antipsychotic treatment on patient's subjective experience and quality of life (QoL) in a sample of clinically stable psychotic subjects. Methods: 26 clinically stable adult schizophrenic and schizoaffective outpatients were recruited. All patients were under a stabilized therapy with a single oral SGA and were switched to the equivalent maintenance regimen with the long-acting formulation of the same antipsychotic. Two subgroups of patients were created on the basis of the presence/absence of a complete clinical remission at enrolment. Anthropometric(BMI), psychometric(MADRS, YMRS and PANSS) and patient's reported outcome(SWN-K, DAI-10 and SF-36) data were collected at enrolment(T0) and after 6 months from the treatment switch(T1). Results: Significant improvements of psychometric indexes, patients' subjective experience of treatment and attitudes towards drug (reflecting in an enrichment of patients' health-related QoL) were found both in remitters and in non-remitters. Conclusions: Our preliminary results suggest that the switch from oral to LAI antipsychotic treatment may help to address the subjective core of an optimal and satisfying recovery of psychotic patients. Size and duration of this study need to be expanded in order to produce more solid and generalizable results.

PMID: 25410156 [PubMed - as supplied by publisher]

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